| abstract |
The invention discloses one group and replace benzo heterocyclic amine derivant and preparation method thereof and the related application as IMPDH inhibitor.IMPDH (carnine acidohydrogenase) inhibitor all has good application prospect in antiviral, immunosuppressant, antitumor, antibacterial and parasiticide etc., the present invention is by studying with the design of the IMPDH reactive compound being target spot, synthesis and screening active ingredients, the IMPDH inhibitor of the class new construction shown in acquisition formula (I), the exploitation application for this compounds medicine as dependent interactions such as antiviral, antitumor, immunosuppressant and Pharmaceutical composition thereof is laid a good foundation. |