http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103992297-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D305-12 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D305-12 |
| filingDate | 2014-06-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2016-04-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2016-04-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-103992297-B |
| titleOfInvention | A kind of preparation method of Lipstatin |
| abstract | The invention belongs to medical art, in particular to a kind of preparation method of Lipstatin, more particularly relate to a kind of polar solvent and non-polar solvent of utilizing and alternately extract the technique preparing Lipstatin that phase inversion removal of impurities, freezing removal of impurities and crystallization removal of impurities are core technology.Specifically comprise the pre-treatment of fermented liquid, filter cake lixiviate, concentrated, nonpolar solvent extraction, concentrated, polar solvent extract, freezing removal of impurities, concentrated, non-polar solvent crystallization.Adopt the intermediate prepared of present invention process, total recovery is more than 80%, and content is up to 85.3%, and purity is 96.5%, is extremely conducive to the hydrogenation synthesis of Lipstatin and follow-up refining.In addition, present invention process route is short, and good product quality is easy to operate, and facility investment is few, and solvent load is little, and recyclablely applies mechanically, and significantly reduces production cost and environmental pollution. |
| priorityDate | 2014-06-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 71.