http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103992234-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C213-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C217-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C213-08 |
| filingDate | 2014-06-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2016-05-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2016-05-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-103992234-B |
| titleOfInvention | A kind of preparation method of tamoxifen citrate E isomers |
| abstract | The invention provides a kind of preparation method of tamoxifen citrate E isomers, comprise the steps: 1) taking structural formula suc as formula the intermediate of preparing tamoxifen citrate shown in I as raw material, in the mixed solution of a certain proportion of water and organic solvent, under acid condition, carry out dehydration, obtain the mixture of structural formula intermediate 2 as shown in formula III suc as formula the intermediate 1 shown in II and structural formula; 2) in a certain amount of organic solvent, intermediate 1, intermediate 2 and citric acid or its hydrate reaction, cooling crystallization obtain structural formula suc as formula the Z-tamoxifen citrate shown in IV and structural formula the mixture suc as formula the E-tamoxifen citrate shown in V; 3) in a certain proportion of water and organic solvent, the mixture of Z-tamoxifen citrate and E-tamoxifen citrate is carried out to recrystallization twice. The present invention can prepare high-purity tamoxifen citrate E isomers, for Zhong Jian institute provides impurity reference substance, has solved the problem in actual production process, E-isomers being detected. |
| priorityDate | 2014-06-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 47.