| abstract |
The compound of formula I and its stereoisomers and pharmaceutically acceptable salts and solvates are inhibitors of one or more JAK kinases and are suitable for the treatment of autoimmune diseases, inflammatory diseases, rejection of transplanted organs, tissues and cells, and blood Diseases and malignant tumors and their comorbidities, wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , X 1 and X 2 have the meanings given in the specification. |