http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103987407-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D519-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6849 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D519-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D243-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6849 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6803 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-50 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D519-00 |
| filingDate | 2012-10-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2016-08-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2016-08-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-103987407-B |
| titleOfInvention | Pyrrolobenzodiazepines and their conjugates |
| abstract | A conjugate of formula (A): the dotted line indicates the optional presence of a double bond between C1 and C2 or C2 and C3 ; R2 is independently selected from H, OH, =O, = CH2 , CN, R , OR, =CH- RD, =C(R D ) 2 , O-SO 2 -R, CO 2 R and COR, and optionally further selected from halogen or dihalogen; wherein R D is independently selected from R , CO 2 R, COR, CHO, CO 2 H and halogen; R 6 and R 9 are independently selected from H, R, OH, OR, SH, SR, NH 2 , NHR, NRR', NO 2 , Me 3 Sn and halogen; R 7 is independently selected from H, R, OH, OR, SH, SR, NH 2 , NHR, NRR', NO 2 , Me 3 Sn and halogen; Y is selected from a single bond and a group of formula A1 or A2 Group: where N shows where the group binds to N10 of the PBD moiety; RL1 and RL2 are independently selected from H and methyl, or together with the carbon atom to which they bind form a cyclopropylene group; CBA means cell-associated Q is independently selected from O, S and NH; R 11 is H or R or, wherein Q is O, SO 3 M, wherein M is a metal cation; R and R' are each independently selected from optionally substituted C 1-12 alkyl, C 3-20 heterocyclyl and C 5-20 aryl, and optionally involving the group NRR', R and R' together with the nitrogen atom to which they are attached form an optionally substituted 4- , 5-, 6-, or 7-membered heterocycle; wherein R 12 , R 16 , R 19 and R 17 are as defined for R 2 , R 6 , R 9 and R 7 ; wherein R” is C 3- 12 Alkylene whose chain may be interrupted by one or more heteroatoms such as O, S, N(H), NMe and/or aromatic rings such as benzene or pyridine, which rings are optionally substituted; X and X' independently selected from O, S and N(H). |
| priorityDate | 2011-10-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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