http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103981248-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P41-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P13-06 |
| filingDate | 2014-04-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2016-03-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2016-03-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-103981248-B |
| titleOfInvention | A kind of leucic method of resolution of racemic |
| abstract | The present invention is a kind of leucic method of resolution of racemic, the method prepares left-handed leucine and dextrorotation leucine with Enzymatic Resolution racemize leucine and DL-LEUCINE, specifically comprise the following steps: the first step: with racemize leucine for raw material, prepare DL-LEUCINE methyl ester hydrochloride according to thionyl chloride method; Second step: DL-LEUCINE methyl ester hydrochloride is dissolved in alkaline aqueous solution, adds lipase, enzymatic hydrolysis 5 ~ 10 hours at 30 ~ 40 DEG C of temperature, cool to room temperature gradually again, filter out insolubles, obtain left-handed leucine and L-Leu, and retain filtrate; 3rd step: second step gained filtrate continues hydrolysis in the basic conditions, terminates the neutralization of rear diluted acid, filters to obtain dextrorotation leucine and D-Leu.Splitting solvent for use is water, and production cost is low, and environmental pollution is little; Preparation technology is simple, process is purified conveniently, equipment requirements is not high. |
| priorityDate | 2014-04-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 79.