http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103980208-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F7-0812 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D239-94 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-94 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F7-10 |
| filingDate | 2014-05-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2016-04-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2016-04-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-103980208-B |
| titleOfInvention | The preparation method of Tarceva and derivative thereof |
| abstract | The invention discloses the preparation method of Tarceva and derivative thereof.Compound ii (is worked as R by described preparation methodn 2 =H, compound ii=6,7-(2-Mehtoxy-ethoxy)-quinolin-4-amines) (work as R with compound IIIn 1 =SiMe, Rn 3 =I, compound III=3-trimethylsilyl acetylene base-benzene iodide) in organic solvent, under the effect of alkali and elemental copper and/or mantoquita, carry out linked reaction obtain described Tarceva and derivative thereof.The present invention is using elemental copper and/or mantoquita or palladium reagent as the basis of catalyzed reaction, N-(3-acetylene phenyl)-6 is prepared by midbody compound II and compound III, 7-bis-(2-methoxy ethoxy)-4-quinolyl amine hydrochloride (Tarceva, I) and derivative, preparation method's cheaper starting materials of the present invention is easy to get, reaction conditions gentle, side reaction is few, yield is high, environmental pollution is little, is suitable for suitability for industrialized production. |
| priorityDate | 2014-05-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 77.