http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103977002-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4418 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-02 |
| filingDate | 2014-05-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2016-10-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2016-10-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-103977002-B |
| titleOfInvention | 2-amino nicotinic acid nitrile compounds of induction autophagy and application thereof |
| abstract | The invention discloses new application at preparation autophagy derivant and in the disease that can benefit from autophagy induction for treatment for the class 2 amino nicotinic acid nitrile compounds and combinations thereof.The invention belongs to biomedicine field.The general structure of 2 amino nicotinic acid nitrile compounds of the present invention is formula (I).By research, the present invention finds that the mechanism of action of this type of 2 amino nicotinic acid nitrile compounds Induces Autophagy is different from conventional autophagy derivant, it is the mechanism of the expression by raising autophagy mark LC3 II multifunctional protein p62/SQSTM1 related to autophagy simultaneously and induces various kinds of cell, especially tumour cell autophagy.Therefore, the present invention proposition by make 2 amino nicotinic acid nitrile compounds prepare novel autophagy derivant be used for autophagocytosis mechanism research and preparation induction autophagy treatment can benefit from autophagy induce disease in be with a wide range of applications. |
| priorityDate | 2014-05-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 70.