| Predicate |
Object |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-13 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C55-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4709 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4709
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-14 |
| filingDate |
2013-06-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2015-11-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate |
2015-11-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
CN-103974949-B |
| titleOfInvention |
A kind of I type crystallization of 2-maleate of tyrosine kinase inhibitor and preparation method |
| abstract |
Provide the I type crystallization of (R, E)-N-(4-(the chloro-4-of 3-(pyridine-2-ylmethoxy) phenyl amino)-3-cyano group-7-ethoxyquinoline-6-base)-3-(1-methylpyrrole alkyl-2-base) acrylamide 2-maleate (be called for short SHR1258 2-maleate), its preparation method, pharmaceutical composition containing this crystal formation.The crystallization of described SHR1258 2-maleate I type has good stability of crystal form and chemical stability, can be used for the medicine preparing the treatment disease relevant with EGFR receptor tyrosine kinase or HER-2 receptor tyrosine kinase. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2020083188-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3378478-A4
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2017129088-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109516976-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109516976-B |
| priorityDate |
2012-07-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |