http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103966186-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-96 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y301-01003 |
| classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12R1-125 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-20 |
| filingDate | 2014-04-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2016-04-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2016-04-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-103966186-B |
| titleOfInvention | A kind of method improving the thermostability of bacillus subtilis lipase A |
| abstract | The invention belongs to technical field of enzyme engineering, relate to a kind of method improving bacillus subtilis lipase A thermostability.The present invention for research object, first obtains its crystalline structure with subtilis fat A from RCSB database, the flexibility in recycling its Different L oop region of analysis on Molecular Dynamics; Via above-mentioned rational analysis, and it is theoretical to combine " proline(Pro) effect ", and glycine residue screening being obtained flexible higher Loop region sports proline(Pro); The sudden change result obtained is screened again by molecular dynamics simulation checking; Finally, tested by the thermostability of bacillus subtilis lipase A mutant strain, the focus residue of checking thermostability transformation. |
| priorityDate | 2014-04-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 143.