http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103965231-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F5-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N30-02 |
| filingDate | 2013-01-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2016-06-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2016-06-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-103965231-B |
| titleOfInvention | For detecting the acid amides boric acid ester of bortezomib intermediate purity, preparation method and application thereof |
| abstract | The present invention relates to a kind of acid amides boric acid ester for detecting bortezomib intermediate purity, there is the compound of following structural formula: optical purity II compound Or diastereomer II ' Wherein X is fluorine, chlorine, bromine or iodine. For the quick detection of the optical purity of Velcade key intermediate (R)-leucine boric acid ester. By a simple step chemical reaction; protecting group of being added lustre to by fluorescence is introduced in (R)-leucine boric acid ester; thus obtaining the amino boric ester derivative with stronger uv-absorbing, this derivative can by quantitative its optical purity of detection fast of efficient liquid phase. The method technological operation is simple, sensitivity and accuracy height. |
| priorityDate | 2013-01-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 40.