http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103965166-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-12 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-12 |
| filingDate | 2014-05-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2016-08-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2016-08-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-103965166-B |
| titleOfInvention | Rabeprazole intermediate impurities 2-{ [4-(3-methoxy propoxy)-3-oxide of mathylpyridine-2-base] methyl sulfur } preparation method of-1H-benzimidazole |
| abstract | The preparation method of rabeprazole intermediate impurities 2 { [4 (3 methoxy propoxy) 3 oxide of mathylpyridine 2 base] methyl sulfur } the 1H benzimidazole that the present invention provides, comprise the following steps: 2 chloromethyl 4 (3 methoxy propoxy) 3 methyl pyridinium chloride are soluble in water, aqueous slkali adjusts pH, organic solvent extracts, and merges and concentrates organic facies；React after the organic solvent of dropping oxidant；Reactant liquor is placed in ice-water bath, drips mercaptobenzimidazole solution, maintains two-phase system room temperature reaction after dropping, and stratification, organic facies is dried；In the cryosel bath that organic facies is placed in, the organic solution of dropping oxidant, drip complete follow-up continuous reaction；Reactant liquor is placed in be poured in aqueous slkali, then is placed in stirring and evenly mixing in ice-water bath, stratification, and the acid of aqueous phase is adjusted to neutrality, and organic solvent extracts, and merges and concentrates organic facies, to obtain final product.The preparation method technique that the present invention provides is simple, high-efficiency and economic, product yield and purity high, be suitable for industrialized production. |
| priorityDate | 2014-05-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 67.