| abstract |
The invention discloses a scopoletin derivative, a preparation method and application thereof. The general formula of the scopoletin derivative is (I), wherein, R is selected from C 1 -C 4 alkyl groups, and X is selected from halogen substituents. The above-mentioned scopoletin derivatives have significant anticoagulant effect, can significantly prolong the coagulation time in vitro, and can quickly enter the blood after oral administration, and play an anticoagulant effect; Farin is equivalent, and the dosage is smaller, and it is easy to control; it has new medical uses for preventing and treating venous thrombosis diseases, and also provides new therapeutic candidate drugs for patients with venous thrombosis diseases. The invention also discloses the preparation method of the scopoletin derivative and its application in the preparation of anticoagulant medicine. |