http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103965063-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C219-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C213-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C213-06 |
| filingDate | 2013-01-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2016-05-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2016-05-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-103965063-B |
| titleOfInvention | Sarpogrelate hydrochloride new preparation process |
| abstract | The present invention discloses a kind of preparation method of sarpogrelate hydrochloride, taking 2-[2-(3-methoxyphenyl) ethyl] phenol is as initial reactant, taking benzyltriethylammoinium chloride as phase transfer catalyst, in toluene, water, becomes ether with epoxychloropropane. Become after ether in autoclave, obtain 1-dimethylamino-3-[2-[2-(3-methoxyphenyl) ethyl with dimethylamine aminolysis] phenoxy group]-2-propyl alcohol. Again in acetone with succinic anhydride esterification, without reclaim change solvent, directly pass into hydrogen chloride gas and become hydrochloride. Finally, obtain sarpogrelate hydrochloride highly finished product with acetone recrystallization, purity is more than 99%. |
| priorityDate | 2013-01-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 48.