http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103961348-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C233-81 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C235-56 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C231-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-245 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-381 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D333-70 |
| filingDate | 2013-02-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2016-08-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2016-08-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-103961348-B |
| titleOfInvention | SENP1 micromolecular inhibitor and application thereof |
| abstract | The invention discloses SENP1 micromolecular inhibitor and application thereof, it is provided that one is containing the SENP1 micromolecular inhibitor that 2 (4 phenyl) 2 oxygen ethyl 4 benzoic acid amino benzoic Acid ester derivant is effective ingredient shown in formula (1) and the application in preparation treatment carcinoma of prostate medicine thereof.The present invention utilizes pharmaceutical chemistry and chemical biology, it is found that a series of micromolecular compound is tested in vitro and can substantially suppress SENP1 activity in some cell lines, design further and optimize SENP1 micromolecular inhibitor, illustrate binding mode and the mechanism regulating SENP1 on its atomic level/molecular level, and its effect in carcinoma of prostate of system evaluation, illustrate pharmacological basis for SENP1 as anti-prostate cancer target.This series micromolecular compound is expected to be developed into the medicine of new anti-prostate cancer tumor, and the exploitation to antitumor drug has great importance. |
| priorityDate | 2013-02-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 194.