| abstract |
The present invention relates to new benzamide derivatives and its pharmaceuticss purposes, more specifically, it is related to the new benzamide derivatives or its pharmaceutically acceptable salt, the prevention of the pain comprising which or pruritus and therapeutic composition of the structural formula with chemical formula 1.The present invention new benzamide derivatives and its pharmaceutically acceptable salt shows outstanding pain inhibition, it is not only nerves animal model, also pain inhibition is shown in other pain induction models of such as formalin model, can be used in suppressing various pains such as nociception pain, Chronic pain.And, for the pruritus model for applying the mechanism and treatment concept established in pain, also confirm with antipruritic efficiency, therefore, as antipruritic disease compositionss, suppress and treat initially to itch the stage, prevention tickles skin injury or inflammatory reaction after the stage, essence so as to be used for allergy is treated, so highly useful. |