http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103951640-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D207-337 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D333-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D307-54 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-40 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-341 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D333-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D207-337 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-381 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D307-54 |
| filingDate | 2014-05-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2016-03-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2016-03-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-103951640-B |
| titleOfInvention | A kind of compound and preparation thereof and purposes |
| abstract | The present invention relates to medical art, particularly relate to a kind of compound and preparation thereof and purposes.This compound has structure shown in formula I, the present invention adopts computer simulation and molecular docking technology, filters out the compound of structure shown in formula I, confirms that this compound has the effect suppressing PI3K path, restraining effect is played to the growth of tumour and activity, and can the apoptosis of inducing tumor cell.Experiment shows, compound provided by the invention is expressed the key enzyme in PI3K signal path and phosphorylation can play obvious restraining effect, this restraining effect has obvious time-dependent manner and concentration dependent, and, experiment proves that compound provided by the invention restraining effect can not occur to the key enzyme in other pathways metabolisms, can specific suppression PI3K signal path. |
| priorityDate | 2014-05-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 268.