http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103951640-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_65682d3e437c225d79b93953b4b26392 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D207-337 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D333-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D307-54 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D207-337 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-381 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D333-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-341 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-40 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D307-54 |
| filingDate | 2014-05-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9bed27921637b13f2722895485ce0920 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8db41f42056fd72bdd03de7301bfcb84 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d434a76779f8bfe416ece16682da60d2 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_52ef2a189b2a176b99f6cc94a86f2a68 |
| publicationDate | 2014-07-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-103951640-A |
| titleOfInvention | A kind of compound and its preparation and use |
| abstract | The invention relates to the technical field of medicine, in particular to a compound and its preparation and use. The compound has the structure shown in formula I. The present invention adopts computer simulation and molecular docking technology to screen out the compound with the structure shown in formula I, and it is confirmed that the compound has the effect of inhibiting PI3K pathway and inhibiting the growth and activity of tumors. And can induce the apoptosis of tumor cells. Experiments show that the compound provided by the invention can significantly inhibit the expression and phosphorylation of key enzymes in the PI3K signaling pathway, and the inhibition has obvious time-dependence and concentration-dependence, and the experiment proves that the compound provided by the invention The compound does not inhibit key enzymes in other metabolic pathways, and can specifically inhibit the PI3K signaling pathway. |
| priorityDate | 2014-05-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 29.