http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103951549-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C45-455 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D231-12 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C45-48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C49-80 |
| filingDate | 2014-05-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2016-04-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2016-04-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-103951549-B |
| titleOfInvention | A kind of synthetic method of COX-2 enzyme inhibitors celecoxib intermediate |
| abstract | The invention belongs to clean synthetic technology field, be specifically related to a kind of synthetic method of COX-2 enzyme inhibitors celecoxib intermediate, with Trifluoroacetic Acid Ethyl Ester (II) and p-methyl aceto phenone (I) for starting raw material, alkali is done with carbonate, react in organic solvent, obtain celecoxib (Celecoxib) intermediate product 4,4 with 83 ~ 99% yields, 4 San Fu (4 aminomethyl phenyl) 1,3 dimethyl diketone (III).Whole process raw material consumption is low, alkali and solvent is all recyclablely reused, the three wastes are few, has good industrial prospect. |
| priorityDate | 2014-05-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 132.