| abstract |
The present invention provides pyridine-oxadiazole/thiadiazole derivatives of formula I, wherein A is N or CR 4a , said derivatives are used to restore or enhance the function of mutant and/or wild-type CFTR to treat cystic Fibrosis, primary ciliary dyskinesia, chronic bronchitis, chronic obstructive pulmonary disease, asthma, respiratory infection, lung cancer, xerostomia and keratoconjunctivitis sicca or constipation (IBS, IBD, opioid-induced). Also included are pharmaceutical compositions comprising such derivatives. X is |