| abstract |
It is an object of the invention to provide and directly facilitate based on osteoblastic osteogenetic osteogenesis promoter and the preventive of osteopathia and therapeutic agent.It is a feature of the present invention that the binding inhibitor matter using semaphorins 4D and plexus nervorum element B1.As described binding inhibitor matter, preferable example antinoise signal element 4D antibody, anti-plexus nervorum element B1 antibody, comprise the protein etc. of the extracellular space of plexus nervorum element B1. |