http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103936854-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P19-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-85 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-395 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P17-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P37-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P19-08 |
| filingDate | 2014-04-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2016-08-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2016-08-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-103936854-B |
| titleOfInvention | Anti-IL-17A monoclonal antibody and preparation and application thereof |
| abstract | The monoclonal antibody that the present invention relates to a kind of specific binding IL 17A, the expression vector of the polynucleotide sequence comprising encoding said antibody, host cell, and monoclonal antibody are for preparing the purposes in the disease of immune system that treatment is mediated by IL 17A.It is an object of the invention to go out anti-IL 17A monoclonal antibody from fully synthetic Phage Antibody Library, then by a kind of method of fully synthetic phage antibody library building low capacity rite-directed mutagenesis, the variable region of heavy chain CDR3 region mutation of the anti-IL 17A monoclonal antibody filtered out is built storehouse and carries out antibody in vitro affinity maturation, the final antibody obtaining high-affinity, adds the diversity of antibody library simultaneously. |
| priorityDate | 2014-04-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 145.