| abstract |
The invention belongs to the technical field of medicine, and provides a preparation method of optically-pure argatroban represented by the formula A. In the preparation method, a compound represented by a formula I is subjected to a transfer hydrogenation reaction in the presence of a chiral catalyst so as to obtain the argatroban represented by the formula A. The preparation method provided by the invention has the advantages of mild conditions, simple operation, high yield, low production cost, and suitability for massive production. |