http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103936666-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D211-86 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D211-86 |
| filingDate | 2014-04-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2016-01-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2016-01-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-103936666-B |
| titleOfInvention | A kind of synthetic method of 2,4-dioxopiperidine |
| abstract | The invention discloses a kind of 2; 4-dioxopiperidine synthetic method; the method with malonic acid monomethyl ester and 3-aminopropanoate hydrochloride or 3-alanine carbethoxy hydrochloride for initial feed; take methylene dichloride as solvent, dicyclohexylcarbodiimide (DDC) is react under the condition of acid binding agent as dewatering agent, triethylamine; acidylate condensation product methyl-3-((3-methoxyl group-3-carbonyl propyl group) is amino)-3-carbonyl propionic acid ester; using salt as catalyzer in acidylate condensation reaction, this catalyst selectivity is good, side reaction is few, yield is higher.Then under the effect of sodium methylate, cyclization shortens 3-(methoxycarbonyl (methoxycarbonyl))-4-carbonyl-1 into, 4,5,6-tetrahydropyridine-2-alkyd sodium, then decarboxylation becomes 2 in hydrochloric acid system, 4-dioxopiperidine, in whole reaction, because methoxyl group is easily sloughed, reaction raw materials is easy to get, reaction conditions is gentle, operational safety and transformation efficiency is high. |
| priorityDate | 2014-04-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 48.