| abstract |
The invention provides a method for performing gold-catalyzed selective C-H bond functionalization on phenol and aniline, which comprises the following steps: by taking phenol and aniline compounds as raw materials and taking phosphine ligand or carbene as ligand, in organic solvent, reacting with a diazo compound in the presence of a gold catalyst and a silver salt, performing carbon-hydrogen bond insertion at the para-position or ortho-position of the phenol or aniline structure. The method provided by the invention has the characteristics of low catalyst consumption, mild conditions, wide substrate application range and the like; the method can be used for quickly and efficiently synthesizing methyl acetate derivatives containing the phenol or aniline structure; and meanwhile, the method can be used for performing later modification on natural products or drug molecules (such as estrone), or be used for synthesizing some molecules having biological activity, thus having favorable application prospects. |