http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103933584-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K49-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K49-18 |
| filingDate | 2014-04-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2016-08-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2016-08-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-103933584-B |
| titleOfInvention | A kind of preparation method of the superparamagnetic iron oxide nano-particle of modified with folic acid |
| abstract | The present invention relates to the preparation method of the superparamagnetic iron oxide nano-particle of a kind of modified with folic acid, including: gentle reducing process prepares the superparamagnetic iron oxide nano-particle (USPIO PEI) of PEI cladding；USPIO PEI nano grain surface modifies folic acid composite (COOH PEG FA) and Fluorescein isothiocyanate (FI)；And the acetylation modification of nano grain surface.Present invention process is simple, and reaction condition is gentle, it is easy to operation；The superparamagnetic iron oxide nano particle diameter of preparation is less, relaxation rate superelevation, and has good colloidal stability, biocompatibility and specific tumor-targeting, and cancer target imaging diagnostic field has potential using value in vivo. |
| priorityDate | 2014-04-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 38.