| abstract |
The invention discloses a kind of three flute profiles connexon and its application, the three flute profiles connexon can be used for obtaining antibody drug conjugates.The antibody drug conjugates are as shown in formula I：L–(T–A–D) n I wherein L is antibody, antibody fragment or albumen；T is three flute profile connexon parts；A is can be broken connection sub-portfolio or can not be broken connexon part；D is drug moiety；N is integer of the scope 18；The structure of the three flute profiles connexon part is as shown in formula II： Wherein W is the aryl of substitution, heteroaryl, alkyl group, cycloalkyl, Heterocyclylalkyl, or be wherein combined. |