http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103933557-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00 |
| filingDate | 2014-04-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2015-11-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2015-11-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-103933557-B |
| titleOfInvention | A kind of gliomatous two-ways regulation therapeutic vaccine and preparation method thereof |
| abstract | The invention discloses a kind of gliomatous two-ways regulation therapeutic vaccine and preparation method thereof, this vaccine is the complex of FAT10 multivalence epitope peptide and Tim-3 gene recombinant vectors; FAT10 multivalence epitope peptide is by epi-position FAT10n 154-162 / FAT10n 155-163 / FAT10n 49-57 with wear film sequence HIV-Tat40-48, ER retention signal sequence D ELK and joint sequence and form, wear film sequence and be positioned at aminoterminal, ER retention signal sequence is positioned at c-terminus, and epi-position is connected with joint sequence with wearing between film sequence or ER retention signal sequence; This vaccine successfully can enter cell and targeting endoplasmic reticulum, effectively promotes epi-position FAT10n 154-162 / FAT10n 155-163 / FAT10n 49-57 entering MHC-I class antigen presentation approach excites specific CTL to reply, and Tim-3 plays Immunosuppression escape effect simultaneously, assists to stimulate T cell activation, thus produces immune activation effect widely, the antineoplastic immune of inducing potent. |
| priorityDate | 2014-04-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 105.