| abstract |
The present invention provides neuroprotective polyphenolic compounds, which may be synthetic analogs of fisetin, baicalein or chlorogenic acid, which retain neuroprotective, anti-inflammatory, glutathione-promoting and/or anti-inflammatory properties. Oxidizing properties. The neuroprotective polyphenolic compounds are useful for promoting, enhancing and/or increasing neuronal protection, growth and/or regeneration. The polyphenolic compounds can also be used to increase and/or maintain intracellular glutathione (GSH) levels. The polyphenolic compounds are also useful for treating, preventing, alleviating and/or delaying neurodegenerative disorders, including diabetes, Parkinson's disease, Huntington's disease, Alzheimer's disease, non-Alzheimer's dementia, multiple sclerosis, traumatic brain injury, spinal cord injury, or ALS. |