http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103923983-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-178 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-158 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6886 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-113 |
| filingDate | 2014-03-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2017-04-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2017-04-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-103923983-B |
| titleOfInvention | Detection and application of long-chain non-coding RNA of remarkable up regulation in esophageal squamous carcinoma |
| abstract | The invention discloses detection and application of a long-chain non-coding RNA of remarkable up regulation in esophageal squamous carcinoma. The invention relates to discovery, detection and application of a long-chain non-coding RNA. Specific real-time quantitative PCR (Polymerase Chain Reaction) primers are designed and synthesized according to a sequence of the long-chain non-coding RNA, the expression level of the long-chain non-coding RNA is detected in a specimen of an esophagus cancer clinical case by using a real-time quantitative PCR preparation, and the remarkable up regulation of the long-chain non-coding RNA during expression in the esophageal squamous carcinoma is discovered. The invention is expected to prepare a preparation for auxiliary diagnosis or therapeutic effect prediction of the esophagus cancer. In addition, two siRNA (small interfering RNA) sequences for specifically knocking the expression of the long-chain non-coding RNA down are designed and synthesized, experiments prove that after the expression level of the long-chain non-coding RNA is knocked down in a human esophageal squamous carcinoma cell strain, transfer number of tumor cells is remarkably reduced, and thus the siRNA sequences disclosed by the invention are also expected to serve as a tool of molecular targeting treatment for a patient suffering from the esophageal squamous carcinoma. |
| priorityDate | 2014-03-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 69.