http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103923847-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_cb351a5a4e03ee3773bd0df5dbae9ac3 |
| classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12R1-645 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N1-19 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-81 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P7-50 |
| filingDate | 2014-03-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e2851d8ff655108604d2d698eb73aa24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8a548b8ddae38256affd39a7a2eb8b1f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_85b383a68e3b72e8b4fe49671460dab7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_de2ca0225c9445cb07131cc2a76bd00a |
| publicationDate | 2014-07-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-103923847-A |
| titleOfInvention | Yarrowia lipolytica capable of reinforcing precursor supply to enhance synthesis of alpha-oxoglutarate |
| abstract | The invention discloses Yarrowia lipolytica capable of reinforcing precursor supply to enhance synthesis of alpha-oxoglutarate, belonging to the technical field of metabolic engineering. According to the invention, catalytic activity of a pyruvate dehydrogenase E1 component in a cell is improved through overexpression of PDA1, so the accumulation of an intermediate metabolite pyruvic acid is decreased, and supply of intracellular acetyl-CoA is reinforced; moreover, supply of intracellular acetyl-CoA is increased for accumulation of alpha-oxoglutarate for cells, which enables extracellular accumulation of alpha-oxoglutarate to be obviously increased. Thus, overexpression of PDA1 enables the content of the intermediate metabolite pyruvic acid to be decreased and accumulation of alpha-oxoglutarate to be reinforced and provides novel thinking for accumulation of organic acid in TCA cycle for cells. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110499259-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110499259-B http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-104357344-A |
| priorityDate | 2014-03-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 69.