http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103923025-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D249-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4192 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P17-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D249-04 |
| filingDate | 2014-04-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2015-10-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2015-10-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-103923025-B |
| titleOfInvention | A kind of chalcone derivative based on click chemistry and preparation method and purposes |
| abstract | The present invention relates to a kind of chalcone derivative based on click chemistry and preparation method and purposes, this compounds with 4 '-propynyloxy base cinnamophenone for raw material, under the catalysis of anhydrous cupric sulfate/sodium ascorbate system, the nitrine methylene-benzene of replacement different from phenyl ring is obtained by reacting.And tyrosinase activity test has been carried out to synthesized new compound.Experimental result shows: compound 3a, and 8a, 9a, 15a have certain activation tyrosinase activity, and compound 10a, 14a have and activate tyrosinase activity preferably, its ECn 50 be less than positive drug 8-methoxy Psoralea corylifolia.The method reaction conditions is gentle, and experimental procedure is simple and direct, the purposes of chalcone derivative in preparation treatment leucoderma medicament based on click chemistry of the present invention. |
| priorityDate | 2014-04-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 99.