| abstract |
An improved preparation method of aripiprazole intermediate 7-(4-bromobutoxy)-3,4-dihydroquinolone, which includes in alcohol solvent, 3,4-dihydro-7- Hydroxy-2(1H)-quinolinone reacts with 1,4-dibromobutane under the catalysis of base in the presence of polyethylene glycol (PEG). The reaction yield of the invention is over 90%, the high-performance liquid phase (HPLC) purity of the product is over 93%, the reaction time is short, the energy consumption is low, the solvent recovery is convenient, and the cost can be reduced. |