http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103922986-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C271-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C233-83 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D207-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C229-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C227-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F7-18 |
| filingDate | 2013-01-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2017-02-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2017-02-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-103922986-B |
| titleOfInvention | Vildagliptin, vildagliptin analogues and vildagliptin intermediate, and preparation methods of three and application |
| abstract | The invention discloses vildagliptin, vildagliptin analogues and a vildagliptin intermediate, and preparation methods of the above compounds and application. The invention provides the vildagliptin analogues shown as a general formula 10, wherein R1 is triethylsilyloxy group, trifluoroacetoxy group, benzyloxy group, tert-butyldimethylsiloxy group, and R2 is cyano group or formamido group. The provided preparation method for the anti-diabetic medicine vildagliptin and the vildagliptin analogues is mild in reaction conditions, less in by-products, high in conversion rate, simple in post-treatment operation, high in product yield, good in purity, low in production cost and good in industrialization prospect. The invention provides a key intermediate N-substituted pyrrolidine compound 1 for preparing the anti-diabetic medicine vildagliptin and the vildagliptin analogues, and a preparation method of the intermediate. The synthetic method is simple in reaction conditions, cheap and easily available in raw materials, relatively high in both conversion rate and yield, low in cost, friendly in environment and suitable for industrial production. The general formula 10 is shown in the specification. |
| priorityDate | 2013-01-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 346.