http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103910886-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L27-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08B37-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08G81-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L27-52 |
| filingDate | 2014-03-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2016-04-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2016-04-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-103910886-B |
| titleOfInvention | Application in the conjugates of hyaluronic acid of halfcystine functionalization and synthetic method thereof and the hydrogel that formed at Injectable in-situ |
| abstract | The invention discloses the conjugates of hyaluronic acid of halfcystine functionalization and synthetic method thereof and preparing the application in the hydrogel that Injectable in-situ formed.The method is by modifying hyaluronic hydroxyl, obtain the conjugates of hyaluronic acid of the halfcystine functionalization with stable ehter bond, in this reaction process, introduce this novel method of TBAH add hyaluronic solubleness and improve reaction efficiency, the conjugates of hyaluronic acid of the halfcystine functionalization obtained has sulfhydryl reactive group, not only add hyaluronic adhesivity, also can continue function, and the present invention uses the conjugates of hyaluronic acid of prepared halfcystine functionalization and polyethylene glycol conjugate to generate by chemistry ligation or Michael reaction naturally the hydrogel that Injectable in-situ formed, through Research on The Rheology, there is good rheological property, and gellifying property is controlled, have broad application prospects at biomedicine field. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-106478841-A |
| priorityDate | 2014-03-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 119.