| abstract |
The invention discloses glucosan derivatives and proline Complex, crystal, preparation method and application.The X ray powder diffraction patterns of the eutectic crystal, when the angle of diffraction is 2 θ, characteristic diffraction peak contains：4.339,11.499,12.835,13.921,15.294,16.212,16.804,17.154,18.335,19.274,19.982,22.710,23.218,24.885,27.940,29.612 and 30.313,2 error range ± 0.1 θ.The preparation method：The solution of compound A is mixed with L proline solution, cooling crystallization.The present invention also provides the application of the crystal in medicine preparation.Eutectic crystalline water-soluble of the present invention is high, hygroscopicity is low, stability is high, is suitable for preparing various dosage formulations. Formulas I. |