http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103910695-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_36ada1c6fb5047a8c0db0a64779e5fda |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D277-56 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D277-56 |
| filingDate | 2014-04-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e3fb29238f2e87d5f1394382d9251d7e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_05e08f44111112b09f81a0d3b095c18f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_486940b379ee214f0d8b29ad8631a19b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f6a9b4d6aab4f30df3af53a560127277 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_db6f6e1eb5a04a91f9fccc08d9812d46 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c45afb7d93d4c1c24533e67c40c37066 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_871cc7cc53ca88b1114079ec0eda603b |
| publicationDate | 2014-07-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-103910695-A |
| titleOfInvention | A kind of synthetic method of febuxostat |
| abstract | The invention discloses a method for synthesizing febuxostat, which mainly comprises: 1) using 4-hydroxythiobenzamide, a compound of formula II, as a raw material to prepare a compound of formula III through a cyclization reaction; 2) making the compound of formula III A nucleophilic aromatic substitution reaction occurs to obtain a compound of formula IV; 3) a compound of formula IV is subjected to a substitution reaction to obtain a compound of formula V; 4) a compound of formula V is subjected to a cyanation reaction to obtain a compound of formula VI; 5) a compound of formula VI is obtained A hydrolysis reaction occurs to obtain febuxostat, a compound of formula I. The preparation method of the invention has the advantages of simple process and is suitable for industrial production, and the synthesized febuxostat product has the advantages of high purity and high yield. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109320474-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109320474-B |
| priorityDate | 2014-04-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 36.