| abstract |
The invention provides a synthesis method of a 2-fluoroarylcarbonyl compound as shown in the formula IV. The synthesis method comprises the steps of converting an arylcarbonyl compound into a corresponding carbonyl oxime ether compound; then, mildly and directly fluorinating a high-selectivity aryl carbon hydrogen bond at the ortho-position of an oximido substituent in the existence of a palladium catalyst, a fluorinated reagent and an additive; finally, hydrolyzing oxime ether again under the action of acid to obtain the 2-fluoroarylcarbonyl compound. The fluorinating method has the advantages of mild reaction conditions, simplicity in operation, good substrate adaptability, high fluorination selectivity and the like, and has relatively high application and research values. |