http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103896911-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D333-22 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-381 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D333-22 |
| filingDate | 2014-03-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2015-12-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2015-12-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-103896911-B |
| titleOfInvention | 2-(3,4-dimethoxy) benzoyl-5-(4-substitutedphenylethynyl base) thiophene and preparation method thereof and application |
| abstract | The invention discloses 2-(3; 4-dimethoxy) benzoyl-5-(4-substitutedphenylethynyl base) thiophene, structural formula is as follows: n ; Its preparation method, comprises step: 1) in the presence of a catalyst, 2-bromothiophene, 3,4-dimethoxy-benzoyl chlorides is reacted in solvent, and subsequent purification is separated to obtain 2-(3,4-dimethoxy) benzoyl-5-bromothiophene; 2) under tetrakis triphenylphosphine palladium, CuI, acid binding agent exist, 2-(3,4-dimethoxy) benzoyl-5-bromothiophene, 4-substitutedphenylethynyl are reacted in solvent, carries out subsequent purification and be separated.This compound is preparing the application in anti-breast cancer target therapeutic agent.This compound is preparing the application in anti-breast cancer reversal agent of drug resistance.Compound of the present invention has obvious Inhibit proliferaton effect to human breast cancer cell and breast cancer cell persister, can be used for preparing anti-breast cancer target therapeutic agent and anti-breast cancer reversal agent of drug resistance.And compound of the present invention possesses the potentiality of large-scale industrial production, advantage of lower cost. |
| priorityDate | 2014-03-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 38.