http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103896823-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_9fa8910c45b1af474fed9c932f08af19 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D209-94 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D209-56 |
| filingDate | 2012-12-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_37f4e03f9d32014fad2884510985ff70 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e0d426d1f25b7cb025cb4af676fce4d5 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1d032a5ed79fb2e0b8057a14ee46f95f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3552f98709113cc1980481dfa601c0fe http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_218569ddd1cee5740b7242ffe989fb00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8a5eda71e19140d88752bb34730e96ec |
| publicationDate | 2014-07-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-103896823-A |
| titleOfInvention | Preparation method of intermediate of lurasidone |
| abstract | The invention discloses a preparation method of an intermediate of lurasidone. The preparation method of an intermediate 3 of lurasidone comprises the following steps: (1) subjecting a compound represented by the formula 5 to carry out ammonolysis reactions with one or more components selected from urea, ammonium chloride, and organic acid ammonium in an organic solvent so as to obtain a compound 4; (2) subjecting the compound 4 obtained in the step (1) to carry out reactions with H2 in the presence of a palladium-carbon catalyst so as to obtain the intermediate 3 of lurasidone. The preparation method of an intermediate 4 of lurasidone comprising the following steps: in an organic solvent, subjecting one or more components selected from urea, ammonium chloride, and organic acid ammonium to carry out ammonolysis reactions with a compound represented by the formula 5 so as to obtain the intermediate 4 of lurasidone. The preparation method does not need high temperature or high pressure, and has the advantages of simple preparation technology, high yield, and suitability for amplification production. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-114685349-A |
| priorityDate | 2012-12-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 55.