| abstract |
The invention relates to a preparation method of rivastigmine precursor [1-(3-methoxyphenyl)ethyl]dimethylamine. It is characterized in that it includes the following steps: reacting dimethylamine hydrochloride with alkali to generate dimethylamine, reacting with m-methoxyacetophenone in the presence of tetraisopropyl titanate, the reaction time is 5-24 hours, The reaction temperature is 0-50 ° C, in the presence of a catalyst, hydrogen gas is introduced, the reaction temperature is 20-100 ° C, and the reaction time is 12-72 hours, that is, [1-(3-methoxyphenyl) ethyl] dimethyl amine. The preparation method of the invention is normal pressure reaction, has the advantages of mild reaction conditions, less equipment investment, simple and safe operation, environmental friendliness, less pollution, etc., and is beneficial to large-scale industrial production. |