http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103893781-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00 |
| filingDate | 2014-04-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2016-03-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2016-03-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-103893781-B |
| titleOfInvention | Dickkopf-3(DKK3) function and application of gene in coronary atherosclerotic heart disease |
| abstract | The present invention discloses the function and application of a kind of DKK3 gene in coronary atherosclerotic heart disease.The present invention with DKK3 knock out mice and heartspecific DKK3 transgenic mice for experimental subject, myocardial infarction model research is caused by blocking mouse heart ramus descendens anterior arteriae coronariae sinistrae, result shows to contrast with DKK3+ /+control mice, DKK3 knock out mice cardiac infarction ratio, myocardial hypertrophy and Fibrotic degree obviously increase, and cardiac function obviously worsens; And the cardiac infarction ratio of heartspecific DKK3 transgenic mice, myocardial hypertrophy and Fibrotic degree are obviously suppressed, cardiac function obviously improves.Thus find the function of DKK3 gene in coronary atherosclerotic heart disease, be mainly reflected in it and there is the effect can protecting coronary atherosclerotic heart disease.For the above-mentioned functions of DKK3, DKK3 can be used for the medicine preparing treatment coronary atherosclerotic heart disease. |
| priorityDate | 2014-04-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 45.