http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103877066-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-337 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-26 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-51 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 |
| filingDate | 2014-02-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2016-08-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2016-08-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-103877066-B |
| titleOfInvention | Carry preparation method and the application of the self-assembled nanometer grain of docetaxel and sulforaphane |
| abstract | The present invention relates to pharmaceutical technology field, it is provided that a kind of hyaluronic acid decorated PLGA self-assembled nanometer grain carrying docetaxel and sulforaphane, and preparation method thereof with preparation treatment breast cancer medicines in application.The microstructure of nanoparticle of the present invention includes hydrophobic PLGA core and hydrophilic HA shell, and wherein PLGA core is used for bag medicine carrying thing DTX or SFN, and hydrophilic outer shell HA can be with the breast carcinoma stem cell of targeting CD44 acceptor high expressed.Through vitro cytotoxicity experiment, the present invention shows that drug-carrying nanometer particle specific ionization medicine has played more preferable anti-differentiation mammary glandular cell and the ability of breast carcinoma stem cell；Through in-vivo tumour Inhibition test show relatively free drug and associated with free drug more effective, and system toxicity is little.The nanoparticle of the present invention can reach the effect being simultaneously targeting differentiation breast cancer cell core breast carcinoma stem cell, provides a kind of New Policy for breast cancer treatment. |
| priorityDate | 2014-02-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 152.