http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103864925-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02A50-30 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-13 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-46 |
| filingDate | 2014-03-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2016-05-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2016-05-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-103864925-B |
| titleOfInvention | The heavy chain of a kind of senior middle school and active Japanese ence phalitis Viruses monoclonal antibody and variable region of light chain |
| abstract | The invention discloses a kind of senior middle school and active Japanese ence phalitis Viruses monoclonal antibody, adopt mouse brain suspension JEV(SA14) immune BALB/c × Kunming mouse first filial generation, prepare one group of anti-JEV of mouse? mAbs. The present invention has cloned light chain, heavy chain variable region gene and the amino acid sequence of senior middle school and active Japanese ence phalitis Viruses monoclonal antibody, and sequence analysis has confirmed the uniqueness of this antibody sequence. 2F2mAb heavy chain variable region gene CDR of the present invention district is transplanted in the FR of Ren Yuan variable region, forms CDR grafted antibody and also claim reshaped antibody or humanized antibody. Utilize CDR implantation technique engineered antibody, can obtain the specificity that keeps mouse parent mAb, and more approach the novel antibodies of people's antibody, for the preparation of the medicative humanized antibody of popularity encephalitis B, for the anti-epidemic encephalitis B virus genetic engineering antibody that builds high-affinity lays the first stone. |
| priorityDate | 2014-03-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 25.