http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103864877-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J43-00 |
| filingDate | 2012-12-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2016-12-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2016-12-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-103864877-B |
| titleOfInvention | A kind of preparation method of Abiraterone acetate |
| abstract | The invention discloses the synthetic method of a kind of Abiraterone acetate; comprise the steps: 1) under inert gas shielding, room temperature condition, by palladium catalyst and 2 dicyclohexyl phosphines 2 ', 4 '; 6 ' tri isopropyl biphenyls and the mixing of 3 pyridine boronic acid, it is thus achieved that mixture I；2) under inert gas shielding, room temperature condition; catalyst PTS aqueous solution in the basic conditions with compound 17 iodine androstane 5; 16 diene 3 β alcohol acetic ester mixing obtain mixtures II; mixtures II is added step 1) in the mixture I that obtained; react under room temperature or heating condition, it is thus achieved that Abiraterone acetate crude product；3) extract, with saturated aqueous common salt, reaction of going out, use organic solvent I aqueous phase extracted, merge organic relevant dry, concentrating under reduced pressure, then with organic solvent II or organic solvent II and the mixed liquor recrystallization of water, obtain Abiraterone acetate fine work. |
| priorityDate | 2012-12-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 116.