http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103864630-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_aaadcd534c1edeab62f85ec7991cb759 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C213-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C217-62 |
| filingDate | 2014-03-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2015-07-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_197c3d0648260abfa777eda325d08cdf http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_86300adfdf65cfd83290434310e56bc1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2233163b1aa3afbc62bd419d971cbdf3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_744b033e6a0378fd7e857c73ee587ce9 |
| publicationDate | 2015-07-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-103864630-B |
| titleOfInvention | Synthesis method of (S)-1-(4-ethyoxyl benzyl)-3-azapentane-1,5-diamine trihydrochloride |
| abstract | The invention provides a synthesis method of a gadoxetate disodium key precursor-(S-1-(4-ethyoxyl benzyl)-3-azapentane-1,5-diamine trihydrochloride. The synthesis method comprises the following steps: taking O-ethyl-N-Boc-L-tyrosine ethyl ester (a compound 1) as a material; reducing the material by red aluminum to obtain O)-ethyl-N-Boc-L-tyrosine aldehyde (a compound 2); then obtaining 1,5-Boc double-protection (S)-1-(4-ethyoxyl benzyl)-3-azapentane-1,5-diamine (a compound 3) by virtue of amination and reduction with N-Boc-1,2-ethanediamine under catalysis of sodium triacetoxyborohydride; finally, removing Boc protective groups through concentrated hydrochloric acid or a hydrogen chloride gas so as to obtain the (S)-1-(4-ethyoxyl benzyl)-3-azapentane-1,5-diamine trihydrochloride (a compound 4). According to the synthesis method disclosed by the invention, synthesis route steps are novel and concise, dear and dangerous special reagents are not needed, reaction is gentle, a product is easy to purify, after-treatment is convenient, and therefore, the synthetic method is suitable for industrial production. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2017208258-A1 |
| priorityDate | 2014-03-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 53.