| abstract |
Various compounds are provided that are structurally related to the natural compound OSW-1 that binds OSBP. Also provided are pharmaceutical compositions comprising the OSW-1 analogs, and the use of these OSW-1 analogs or pharmaceutically acceptable salts, enantiomers or stereoisomers to treat atherosclerosis, Alzheimer's Methods for Haimer's disease and cancer, including p21-deficient cancers. Also provided are conjugates of OSW-1 analogs and monoclonal antibodies, including monoclonal antibodies that target cancer cells. Also provided are pharmaceutical compositions comprising the conjugates, as well as methods of using the conjugates for treating cancer, including p21-deficient cancers. |