| abstract |
Main purpose of the present invention is to provide a kind of novel Hete rocyclic derivatives or its salt pharmaceutically allowed.As the present invention, the Hete rocyclic derivatives or its tautomer or its salt pharmaceutically allowed that such as represent with following general formula [1] can be exemplified.n in formula, Rn 1 , Rn 2 identical or different, and represent aromatic nucleus etc.; Ring A represents heterocycle.The compounds of this invention or its salt pharmaceutically allowed have high mPGES-1 inhibit activities, can be used as preventive or the therapeutical agent of the disease relevant to mPGES-1, such as rheumatoid arthritis, osteoarthritis, temporomandibular joint disorder, pain in the back, uterine endometrium disease, dysmenorrhoea, overactive bladder, malignant tumour or nerve degenerative diseases. |