| abstract |
The main purpose of the present invention is to provide a novel heterocyclic derivative or a pharmaceutically acceptable salt thereof. The present invention may, for example, be a heterocyclic derivative represented by the following general formula [1] or a tautomer or a pharmaceutically acceptable salt thereof. In the formula, R 1 and R 2 are the same or different, and represent an aromatic ring or the like; Ring A represents a heterocyclic ring. The compounds of the present invention or pharmaceutically acceptable salts thereof have high mPGES-1 inhibitory activity and can be used as mPGES-1-related diseases, such as rheumatoid arthritis, osteoarthritis, temporomandibular joint disorders, low back pain, endometrium A preventive or therapeutic agent for menstrual disorders, dysmenorrhea, overactive bladder, malignant tumors, or neurodegenerative diseases. |