| abstract |
The synthetic method of cefcapene pivoxil hydrochloride of the present invention, the steps are: take 7-aminocephalosporanic acid (7-ACA) as raw material, through "one pot method" 3-position ester hydrolysis and 7-position amino protection, "one pot method" Method "3-position amidation and 7-position deprotection two-step reaction to obtain the important intermediate of cefcapene pivoxil, and then condense with cefcapene pivoxil side chain acid ammonia, and finally the 4-position acid is esterified and salted with acid Obtain the finished product cefcapene hydrochloride. The invention fully utilizes the principle of atom economy to shorten the reaction route, improve the total yield of the reaction, and is beneficial to the improvement and optimization of the process for synthesizing cefcapene hydrochloride. |